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iPSC & Cell Engineering

Patient-specific disease models

Patient-specific models, CRISPR editing, and automated reprogramming.

We engineer isogenic, patient-specific iPSC lines from diverse starting materials, including PBMCs, dermal fibroblasts, and urine-derived epithelial cells (UDEs), using our fully automated pipeline. Our capabilities extend beyond basic reprogramming to include precision CRISPR-mediated editing, offering full gene knockouts, homology-directed repair (HDR), prime editing, and transcriptional modulation (CRISPRa/i) to create exact disease models.

iPSC & Cell Engineering at the iPsomics lab
Core expertise

What we bring to the bench

Automated reprogramming and validation

High-throughput generation with rigorous RNA-seq and scWGS screening.

Precision editing

Reporter gene tagging for real-time monitoring of gene expression and cellular states.

Advanced differentiation

Creation of neurons, cardiomyocytes, brain organoids, intestinal stem cells, and more.

Applications

How it helps your research

Advanced disease modelling

Investigating neurodegenerative disorders (Alzheimer's, Parkinson's) and rare genetic conditions.

Comprehensive safety pharmacology

Cardiotoxicity, hepatotoxicity, and general compound screening to de-risk drug candidates.

Therapeutic development

Genetic correction studies and validation of gene-editing strategies.

Workflow

Your path to results

Our end-to-end iPSC pipeline — from sample to validated disease model.

1
Sample Intake
PBMCs, Fibroblasts, UDEs (Fresh/Cryo)
2
Automated Reprogramming
Non-integrating Sendai Virus
3
Characterization (P10)
RNA-seq for karyotype, pluripotency. Mycoplasma free.
4
Precision Editing
KO, HDR, Prime Editing
5
Differentiation
Neurons, Cardiomyocytes, Organoids
6
Validation & Delivery
Functional assays + scWGS/RNA-seq

Not sure your sample qualifies? Contact us to check →

iPSC & Cell Engineering — common questions

What cell types can you differentiate into?

We routinely produce neurons, cardiomyocytes, brain organoids, intestinal stem cells, and hepatocytes. We also develop custom differentiation protocols on request.

How do you ensure iPSC quality?

Every line undergoes RNA-seq-based karyotyping, pluripotency scoring, and mycoplasma testing at passage 10. We also offer optional scWGS for structural variant screening.

Get in touch

Ready to build your iPSC & Cell Engineering model?

Tell us about your project and we'll scope a solution for your lab.